Crosstalk of inflammatory cytokines within the breast tumor microenvironment

O Habanjar, R Bingula, C Decombat… - International journal of …, 2023 - mdpi.com
Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Potential anti-tumor effects of regulatory T cells in the tumor microenvironment: a review

Y Li, C Zhang, A Jiang, A Lin, Z Liu, X Cheng… - Journal of Translational …, 2024 - Springer
Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for
maintaining immunological balance and are a significant component of the …

[HTML][HTML] Src family kinases as therapeutic targets in advanced solid tumors: what we have learned so far

S Martellucci, L Clementi, S Sabetta, V Mattei, L Botta… - Cancers, 2020 - mdpi.com
Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor
kinase class that controls multiple signaling pathways in animal cells. SFKs activation is …

[HTML][HTML] Role of leptin and adiponectin in carcinogenesis

A Bocian-Jastrzębska, A Malczewska-Herman… - Cancers, 2023 - mdpi.com
Simple Summary The involvement of leptin and adiponectin with receptors in the formation
of many types of cancer as well as their impact on the clinical course of cancer patients are …

Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease

P Pleskač, CA Fargeas, R Veselska, D Corbeil… - Cellular & Molecular …, 2024 - Springer
Abstract Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively
associated with highly curved and prominent membrane structures. It is widely recognized …

Pro-angiogenic activity and vasculogenic mimicry in the tumor microenvironment by leptin in cancer

AK Herrera-Vargas, E Garcia-Rodriguez… - Cytokine & growth factor …, 2021 - Elsevier
The acquired ability to induce the formation of a functional vasculature is a hallmark of
cancer. Blood vessels in tumors are formed through various mechanisms, among the most …

Obese adipose tissue as a driver of breast cancer growth and development: update and emerging evidence

P Bhardwaj, KA Brown - Frontiers in oncology, 2021 - frontiersin.org
Obesity is an established risk factor for breast cancer growth and progression. A number of
advances have been made in recent years revealing new insights into this link. Early events …

Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer

Q Tian, P Yuan, C Quan, M Li, J **ao, L Zhang, H Lu… - Oncogene, 2020 - nature.com
Branched-chain α-keto acid dehydrogenase kinase (BCKDK), the key enzyme of branched-
chain amino acids (BCAAs) metabolism, has been reported to promote colorectal cancer …

Loss of exosomal miR-146a-5p from cancer-associated fibroblasts after androgen deprivation therapy contributes to prostate cancer metastasis

Y Zhang, J Zhao, M Ding, Y Su, D Cui, C Jiang… - Journal of Experimental …, 2020 - Springer
Background Androgen deprivation therapy (ADT) is the backbone of therapy for advanced
prostate cancer (PCa). Despite the good initial response, castration resistance and …

Epigenetic regulation of adipogenesis in development of metabolic syndrome

R Pant, P Firmal, VK Shah, A Alam… - Frontiers in Cell and …, 2021 - frontiersin.org
Obesity is one of the biggest public health concerns identified by an increase in adipose
tissue mass as a result of adipocyte hypertrophy and hyperplasia. Pertaining to the …