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Red blood cell storage lesion: causes and potential clinical consequences
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
Alternatives to blood transfusion
DR Spahn, LT Goodnough - The Lancet, 2013 - thelancet.com
The use of alternatives to allogeneic blood continues to rest on the principles that blood
transfusions have inherent risks, associated costs, and affect the blood inventory available …
transfusions have inherent risks, associated costs, and affect the blood inventory available …
Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine
Transfusion of red blood cells (RBCs) is one of the most valuable and widespread
treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold …
treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold …
Prolonged red cell storage before transfusion increases extravascular hemolysis
BACKGROUND. Some countries have limited the maximum allowable storage duration for
red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 …
red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 …
Haptoglobin therapeutics and compartmentalization of cell-free hemoglobin toxicity
Hemolysis and accumulation of cell-free hemoglobin (Hb) in the circulation or in confined
tissue compartments such as the subarachnoid space is an important driver of disease …
tissue compartments such as the subarachnoid space is an important driver of disease …
“Blood failure” time to view blood as an organ: how oxygen debt contributes to blood failure and its implications for remote damage control resuscitation
CK Bjerkvig, G Strandenes, HS Eliassen… - …, 2016 - Wiley Online Library
Hemorrhagic shock is both a local and systemic disorder. In the context of systemic effects,
blood loss may lead to levels of reduced oxygen delivery (DO2) sufficient to cause tissue …
blood loss may lead to levels of reduced oxygen delivery (DO2) sufficient to cause tissue …
Does prolonged storage of red blood cells cause harm?
WA Flegel, C Natanson, HG Klein - British journal of …, 2014 - Wiley Online Library
Red blood cells (RBC s) degrade progressively during the weeks of refrigerated storage. No
universally accepted definition of 'fresh'or 'old'RBC s exists. While practices vary from …
universally accepted definition of 'fresh'or 'old'RBC s exists. While practices vary from …
Haptoglobin preserves vascular nitric oxide signaling during hemolysis
CA Schaer, JW Deuel, D Schildknecht… - American journal of …, 2016 - atsjournals.org
Rationale: Hemolysis occurs not only in conditions such as sickle cell disease and malaria
but also during transfusion of stored blood, extracorporeal circulation, and sepsis. Cell-free …
but also during transfusion of stored blood, extracorporeal circulation, and sepsis. Cell-free …
Red blood cell storage lesion
R Obrador, S Musulin, B Hansen - Journal of veterinary …, 2015 - Wiley Online Library
Objective To summarize current understanding of the mechanisms responsible for changes
occurring during red blood cell (RBC) storage, collectively known as the storage lesion, and …
occurring during red blood cell (RBC) storage, collectively known as the storage lesion, and …
Red blood cells stored 35 days or more are associated with adverse outcomes in high‐risk patients
BACKGROUND Clinical trials have shown that longer red blood cell (RBC) storage duration
does not worsen outcomes; however, these studies included few RBCs near the end of the …
does not worsen outcomes; however, these studies included few RBCs near the end of the …