HIV-1 capsid: the multifaceted key player in HIV-1 infection
EM Campbell, TJ Hope - Nature Reviews Microbiology, 2015 - nature.com
In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core
made from the viral capsid (CA) protein. The CA protein and the structure into which it …
made from the viral capsid (CA) protein. The CA protein and the structure into which it …
TRIM family proteins: retroviral restriction and antiviral defence
Members of the tripartite motif (TRIM) protein family are involved in various cellular
processes, including cell proliferation, differentiation, development, oncogenesis and …
processes, including cell proliferation, differentiation, development, oncogenesis and …
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor
The host restriction factor TRIM5α mediates species-specific, early blocks to retrovirus
infection; susceptibility to these blocks is determined by viral capsid sequences. Here we …
infection; susceptibility to these blocks is determined by viral capsid sequences. Here we …
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
There is an urgent need for antivirals to treat the newly emerged severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a …
syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a …
HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency
T Schaller, KE Ocwieja, J Rasaiyaah, AJ Price… - PLoS …, 2011 - journals.plos.org
Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally
differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC …
differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC …
Prolyl cis-trans isomerization as a molecular timer
Proline is unique in the realm of amino acids in its ability to adopt completely distinct cis and
trans conformations, which allows it to act as a backbone switch that is controlled by prolyl …
trans conformations, which allows it to act as a backbone switch that is controlled by prolyl …
Evasion of cGAS and TRIM5 defines pandemic HIV
L Zuliani-Alvarez, ML Govasli, J Rasaiyaah… - Nature …, 2022 - nature.com
Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans,
only one, leading to human immunodeficiency virus (HIV) type 1 (M) has become pandemic …
only one, leading to human immunodeficiency virus (HIV) type 1 (M) has become pandemic …
Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1
Abstract In Old World primates, TRIM5-α confers a potent block to human immunodeficiency
virus type 1 (HIV-1) infection that acts after virus entry into cells,,,,. Cyclophilin A (CypA) …
virus type 1 (HIV-1) infection that acts after virus entry into cells,,,,. Cyclophilin A (CypA) …
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly
The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration
site selection, and is the target of multiple host cell and pharmacologic ligands. However …
site selection, and is the target of multiple host cell and pharmacologic ligands. However …
Intrinsic immunity: a front-line defense against viral attack
PD Bieniasz - Nature immunology, 2004 - nature.com
In addition to the conventional innate and acquired immune responses, complex organisms
have evolved an array of dominant, constitutively expressed genes that suppress or prevent …
have evolved an array of dominant, constitutively expressed genes that suppress or prevent …