Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …

Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

Intermediate species in the assembly of amyloid filaments are believed to play a central role
in neurodegenerative diseases and may constitute important targets for therapeutic …

Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …

Abstract Positron Emission Tomography (PET) ligands have advanced Alzheimer's disease
(AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identify AD brain …

The microtubule-associated protein tau aggregates into neurofibrillary tangles in Alzheimer's
disease (AD). The main type of aggregates, the paired helical filaments (PHF), incorporate …

Prion strains in a given type of mammalian host are distinguished by differences in clinical
presentation, neuropathological lesions, survival time, and characteristics of the infecting …

Distinct tau amyloid assemblies underlie diverse tauopathies but defy rapid classification.
Cell and animal experiments indicate tau functions as a prion, as different strains …

Mammalian prions are lethal transmissible pathogens that cause fatal neurodegenerative
diseases in humans and animals. They consist of fibrils of misfolded, host-encoded prion …

Neurodegenerative diseases are commonly associated with the formation of aberrant
protein aggregates within the brain, and ultrastructural analyses have revealed that the …