Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
A Mitrofanova, S Merscher, A Fornoni - Nature Reviews Nephrology, 2023 - nature.com
Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …
prevalence. Among several pathogenetic mechanisms responsible for disease progression …
Potentials of natural antioxidants in reducing inflammation and oxidative stress in chronic kidney disease
OYA Lee, ANN Wong, CY Ho, KW Tse, AZ Chan… - Antioxidants, 2024 - mdpi.com
Chronic kidney disease (CKD) presents a substantial global public health challenge, with
high morbidity and mortality. CKD patients often experience dyslipidaemia and poor …
high morbidity and mortality. CKD patients often experience dyslipidaemia and poor …
Metabolic communication by SGLT2 inhibition
BACKGROUND: SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect
the kidneys and heart, but the underlying mechanism remains poorly understood …
the kidneys and heart, but the underlying mechanism remains poorly understood …
Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients
Diabetic kidney disease (DKD) can lead to end-stage kidney disease (ESKD) and mortality;
however, few mechanistic biomarkers are available for high-risk patients, especially those …
however, few mechanistic biomarkers are available for high-risk patients, especially those …
Digging deep into cells to find mechanisms of kidney protection by SGLT2 inhibitors
KR Tuttle - The Journal of clinical investigation, 2023 - Am Soc Clin Investig
The sodium-glucose cotransporter-2 (SGLT2) is expressed on the luminal side of proximal
tubule epithelial cells in the kidney. While pharmacological inhibition of SGLT2 provides …
tubule epithelial cells in the kidney. While pharmacological inhibition of SGLT2 provides …
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
Chronic kidney disease (CKD), defined as persistent (> 3 months) kidney functional loss,
has a growing prevalence (> 10% worldwide population) and limited treatment options …
has a growing prevalence (> 10% worldwide population) and limited treatment options …
State-of-the-Art-Review: mechanisms of action of SGLT2 inhibitors and clinical implications
V Vallon - American Journal of Hypertension, 2024 - academic.oup.com
BACKGROUND Inhibitors of the Na+-coupled glucose transporter SGLT2 (SGLT2i) primarily
shift the reabsorption of large amounts of glucose from the kidney's early proximal tubule to …
shift the reabsorption of large amounts of glucose from the kidney's early proximal tubule to …
Youth-onset type 2 diabetes: an overview of pathophysiology, prognosis, prevention and management
A Titmuss, S Korula, B Wicklow, KJ Nadeau - Current diabetes reports, 2024 - Springer
Purpose of review: This review explores the emerging evidence regarding pathogenesis,
future trajectories, treatment options, and phenotypes of youth-onset type 2 diabetes (T2D) …
future trajectories, treatment options, and phenotypes of youth-onset type 2 diabetes (T2D) …
Kidney considerations in pediatric obesity
Abstract Purpose of Review Chronic kidney disease (CKD) is a common condition and a
major cause of morbidity and mortality in adults, but children and adolescents are also at risk …
major cause of morbidity and mortality in adults, but children and adolescents are also at risk …
[HTML][HTML] Novel mechanisms of salt-sensitive hypertension
A high dietary sodium-consumption level is considered the most important lifestyle factor that
can be modified to help prevent an increase in blood pressure and the development of …
can be modified to help prevent an increase in blood pressure and the development of …