Extended-spectrum β-lactamase (ESBL)-producing Gram-negative pathogens are a major
cause of resistance to expanded-spectrum β-lactam antibiotics. Since their discovery in the …

Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Resistance to β-lactam antibiotics in Gram-negative bacteria is commonly associated with
production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and …

The substantial use of antibiotics in the clinic, combined with a dearth of new antibiotic
classes, has led to a gradual increase in the resistance of bacterial pathogens to these …

Since its introduction in the 1950s, colistin has been used mainly as a topical treatment in
human medicine owing to its toxicity when given systemically. Sixty years later, colistin is …

Objectives To gain a more detailed understanding of endogenous (mutational) and
exogenous (horizontally acquired) resistance to silver in Gram-negative pathogens, with an …

Chronic wound infections are associated with biofilm formation, which in turn has been
correlated with drug resistance. However, the mechanism by which bacteria form biofilms in …

Livestock may serve as a reservoir for extended-spectrum β-lactamase-producing
Enterobacteriaceae (ESBL-PE). The objectives of this study were to determine the …

Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae has caused a global
pandemic with high prevalence in livestock and poultry, which could disseminate into the …

This study examined the activity of the novel antimicrobial combination ceftazidime-
avibactam against Enterobacteriaceae exhibiting different outer membrane permeability …