Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy
ZQ Wang, ZC Zhang, YY Wu, YN Pi, SH Lou… - Signal transduction and …, 2023 - nature.com
BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …
Epigenetic control of pancreatic cancer metastasis
L Krauß, C Schneider, E Hessmann, D Saur… - Cancer and Metastasis …, 2023 - Springer
Surgical resection, when combined with chemotherapy, has been shown to significantly
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …
Calcium channel blockers potentiate gemcitabine chemotherapy in pancreatic cancer
There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC).
While palliative chemotherapy offers a survival benefit to most patients, nearly all will …
While palliative chemotherapy offers a survival benefit to most patients, nearly all will …
[HTML][HTML] The role of tumor microenvironment in pancreatic cancer immunotherapy: current status and future perspectives
Pancreatic cancer comprises different subtypes, where most cases include ductal
adenocarcinoma (PDAC). It is one of the deadliest tumor types, with a poor prognosis. In the …
adenocarcinoma (PDAC). It is one of the deadliest tumor types, with a poor prognosis. In the …
Precision Medicine for BRCA/PALB2-Mutated Pancreatic Cancer and Emerging Strategies to Improve Therapeutic Responses to PARP Inhibition
DR Principe - Cancers, 2022 - mdpi.com
Simple Summary For the small subset of pancreatic ductal adenocarcinoma (PDAC) patients
with loss-of-function mutations to BRCA1/2 or PALB2, both first-line and maintenance …
with loss-of-function mutations to BRCA1/2 or PALB2, both first-line and maintenance …
Super-enhancers and the super-enhancer reader BRD4: tumorigenic factors and therapeutic targets
H Qian, M Zhu, X Tan, Y Zhang, X Liu, L Yang - Cell Death Discovery, 2023 - nature.com
Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as
critical drivers of tumorigenesis and therapeutic targets. Characterized by substantial …
critical drivers of tumorigenesis and therapeutic targets. Characterized by substantial …
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies
JK Jadlowsky, EO Hexner, A Marshall, SA Grupp… - Nature Medicine, 2025 - nature.com
Long-term risks of gene therapy are not fully understood. In this study, we evaluated safety
outcomes in 783 patients over more than 2,200 total patient-years of observation from 38 T …
outcomes in 783 patients over more than 2,200 total patient-years of observation from 38 T …
Characteristics of anticancer activity of CBP/p300 inhibitors–Features of their classes, intracellular targets and future perspectives of their application in cancer …
M Strachowska, A Robaszkiewicz - Pharmacology & Therapeutics, 2024 - Elsevier
Due to the contribution of highly homologous acetyltransferases CBP and p300 to
transcription elevation of oncogenes and other cancer promoting factors, these enzymes …
transcription elevation of oncogenes and other cancer promoting factors, these enzymes …
Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors
Y Li, Z Shen, K Ratia, J Zhao, F Huang… - Journal of Medicinal …, 2024 - ACS Publications
The bromodomain and extra-terminal domain (BET) proteins are epigenetic readers,
regulating transcription via two highly homologous tandem bromodomains, BD1 and BD2 …
regulating transcription via two highly homologous tandem bromodomains, BD1 and BD2 …
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
PD Talukdar, U Chatterji - Signal Transduction and Targeted Therapy, 2023 - nature.com
Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …
programs that necessitate intricate synergic interactions between transcription factors and …