Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes

LDJ Bos, LB Ware - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

EA Gorman, CM O'Kane, DF McAuley - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic
respiratory failure with bilateral infiltrates on chest imaging, which is not fully explained by …

Ribosome biogenesis in disease: new players and therapeutic targets

L Jiao, Y Liu, XY Yu, X Pan, Y Zhang, J Tu… - … and Targeted Therapy, 2023 - nature.com
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses

J Li, S Deng, J Li, L Li, F Zhang, Y Zou, D Wu… - Cellular & molecular …, 2022 - Springer
Background Acute lung injury (ALI) has received considerable attention in the field of
intensive care as it is associated with a high mortality rate. Obacunone (OB), widely found in …

From ICU syndromes to ICU subphenotypes: consensus report and recommendations for develo** precision medicine in the ICU

AC Gordon, N Alipanah-Lechner, LD Bos… - American journal of …, 2024 - atsjournals.org
Critical care uses syndromic definitions to describe patient groups for clinical practice and
research. There is growing recognition that a “precision medicine” approach is required and …

Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury

PZ Mannes, CE Barnes, J Biermann… - Proceedings of the …, 2023 - National Acad Sciences
The lack of techniques for noninvasive imaging of inflammation has challenged precision
medicine management of acute respiratory distress syndrome (ARDS). Here, we determined …

Rethinking acute respiratory distress syndrome after COVID-19: if a “better” definition is the answer, what is the question?

VM Ranieri, G Rubenfeld, AS Slutsky - American Journal of …, 2023 - atsjournals.org
The definition of acute respiratory distress syndrome (ARDS) has a somewhat controversial
history, with some even questioning the need for the term “ARDS.” This controversy has …

Personalized medicine using omics approaches in acute respiratory distress syndrome to identify biological phenotypes

D Battaglini, L Al-Husinat, AG Normando, AP Leme… - Respiratory …, 2022 - Springer
In the last decade, research on acute respiratory distress syndrome (ARDS) has made
considerable progress. However, ARDS remains a leading cause of mortality in the …

Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice

HX Sha, YB Liu, YL Qiu, WJ Zhong… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Extensive loss of alveolar epithelial cells (AECs) undergoing necroptosis is a crucial
mechanism of acute lung injury (ALI), but its triggering mechanism needs to be thoroughly …

A bibliometric analysis of autophagy in lung diseases from 2012 to 2021

F Lin, Y Chen, W Mo, H Zhou, Z **ao, S Hu… - Frontiers in …, 2022 - frontiersin.org
Background Autophagy refers to the process in which cells wrap their damaged organelles
or unwanted proteins into a double-membrane structure and direct them to lysosomes for …