Severe congenital neutropenias are a heterogeneous group of rare haematological
diseases characterized by impaired maturation of neutrophil granulocytes. Patients with …

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in
organisms ranging from slime molds to mammals. Central to their function is their ability to …

Neutrophils are produced in the bone marrow from stem cells that proliferate and
differentiate to mature neutrophils fully equipped with an armory of granules. These contain …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

The inherited marrow failure syndromes are a diverse set of genetic disorders characterized
by hematopoietic aplasia and cancer predisposition. The clinical phenotypes are highly …

Neutrophil death can transpire via diverse pathways and is regulated by interactions with
commensal and pathogenic microorganisms, environmental exposures, and cell age. At …

We describe a novel clinical phenotype associating T-and B-cell lymphopenia, intermittent
neutropenia, and atrial septal defects in 3 members of a consanguineous kindred. Their …

Neutropenia, defined as an absolute neutrophil count (ANC)< 1.5× 10 9/L, encompasses a
wide range of diagnoses, from normal variants to life-threatening acquired and congenital …

Neutrophils are phagocytes whose principal function is to maintain anti-bacterial immunity.
Neutrophils ingest and kill invading bacteria, releasing cytotoxic, chemotactic and …