Application of targeted mass spectrometry in bottom-up proteomics for systems biology research
The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …
Improving phosphoproteomics profiling using data-independent mass spectrometry
A Srinivasan, JC Sing, AC Gingras… - Journal of Proteome …, 2022 - ACS Publications
Mass spectrometry-based profiling of the phosphoproteome is a powerful method of
identifying phosphorylation events at a systems level. Most phosphoproteomics studies have …
identifying phosphorylation events at a systems level. Most phosphoproteomics studies have …
miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo
S Das, D Bedja, N Campbell, B Dunkerly, V Chenna… - PloS one, 2014 - journals.plos.org
MicroRNAs (miRNAs) are small non-coding RNAs, which inhibit the stability and/or
translation of a mRNA. miRNAs have been found to play a powerful role in various …
translation of a mRNA. miRNAs have been found to play a powerful role in various …
Divergent effects of miR‐181 family members on myocardial function through protective cytosolic and detrimental mitochondrial microRNA targets
Background Micro RNA (miRNA) is a type of noncoding RNA that can repress the
expression of target genes through posttranscriptional regulation. In addition to numerous …
expression of target genes through posttranscriptional regulation. In addition to numerous …
Mitochondrial remodeling: rearranging, recycling, and reprogramming
Mitochondria are highly dynamic and responsive organelles that respond to environmental
cues with fission and fusion. They undergo mitophagy and biogenesis, and are subject to …
cues with fission and fusion. They undergo mitophagy and biogenesis, and are subject to …
Proteomics of the Heart
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …
Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry
A major goal in signaling biology is the establishment of high-throughput quantitative
methods for measuring changes in protein phosphorylation of entire signal transduction …
methods for measuring changes in protein phosphorylation of entire signal transduction …
Map** signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources
Study of the molecular basis of myocardial fibrosis is hampered by limited access to tissues
from human patients and by confounding variables associated with sample accessibility …
from human patients and by confounding variables associated with sample accessibility …
Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond
The ubiquitin–proteasome system (UPS) is the major intracellular degradation system, and
its proper function is critical to the health and function of cardiac cells. Alterations in cardiac …
its proper function is critical to the health and function of cardiac cells. Alterations in cardiac …
Proteomics of human mitochondria
Proteomics have passed through a tremendous development in the recent years by the
development of ever more sensitive, fast and precise mass spectrometry methods. The …
development of ever more sensitive, fast and precise mass spectrometry methods. The …