The impact of cytokines in coronary atherosclerotic plaque: current therapeutic approaches

P Tsioufis, P Theofilis, K Tsioufis… - International Journal of …, 2022 - mdpi.com
Coronary atherosclerosis is a chronic pathological process that involves inflammation
together with endothelial dysfunction and lipoprotein dysregulation. Experimental studies …

MMP-2 and its implications on cardiac function and structure: interplay with inflammation in hypertension

TR Vitorino, AF do Prado, SB de Assis Cau… - Biochemical …, 2023 - Elsevier
Hypertension is one of the leading risk factors for the development of heart failure. Despite
being a multifactorial disease, in recent years, preclinical and clinical studies suggest strong …

Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis

M Gao, M Tang, W Ho, Y Teng, Q Chen, L Bu, X Xu… - ACS …, 2023 - ACS Publications
Atherosclerosis is a common pathology present in many cardiovascular diseases. Although
the current therapies (including statins and inhibitors of the serine protease PCSK9) can …

Inflammation in Heart Failure—Future Perspectives

AM Arvunescu, RF Ionescu, SM Cretoiu… - Journal of Clinical …, 2023 - mdpi.com
Chronic heart failure is a terminal point of a vast majority of cardiac or extracardiac causes
affecting around 1–2% of the global population and more than 10% of the people above the …

Single‐cell immune profiling in coronary artery disease: The role of state‐of‐the‐art immunophenoty** with mass cytometry in the diagnosis of atherosclerosis

KA Kott, ST Vernon, T Hansen, M de Dreu… - Journal of the …, 2020 - Am Heart Assoc
Coronary artery disease remains the leading cause of death globally and is a major burden
to every health system in the world. There have been significant improvements in risk …

[HTML][HTML] Major adverse cardiovascular events: the importance of serum levels and haplotypes of the anti-inflammatory cytokine interleukin 10

S Schulz, L Reuter, A Navarrete Santos, K Bitter… - Biomolecules, 2024 - mdpi.com
Background: Cardiovascular diseases (CVDs) represent major medical and socio-economic
challenges worldwide. There is substantial evidence that CVD is closely linked to …

Resveratrol increases the activation markers and changes the release of inflammatory cytokines of hepatic stellate cells

CM de Oliveira, LAM Martins, AC de Sousa… - Molecular and cellular …, 2021 - Springer
Abstract The phytoalexin Resveratrol (3, 5, 4′-trihydroxystilbene; RSV) has been related to
numerous beneficial effects on health by its cytoprotection and chemoprevention activities …

Targeting immune cell recruitment in atherosclerosis

Y Döring, EPC van der Vorst, C Weber - Nature Reviews Cardiology, 2024 - nature.com
Atherosclerosis is the primary underlying cause of myocardial infarction and stroke.
Atherosclerotic cardiovascular disease is characterized by a chronic inflammatory reaction …

Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease

F Trindade, L Perpetuo, R Ferreira, A Leite-Moreira… - Biomarkers, 2021 - Taylor & Francis
The increasing prevalence of periodontal and cardiovascular diseases is the result of a
sedentary lifestyle associated with poor diet, obesity, hypercholesterolaemia, smoking …

IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults' Clinical Characteristics

RS Freitas, CM de Souza Silva, C Ferreira Fratelli… - Nutrients, 2024 - mdpi.com
Populational aging is marked by chronic noncommunicable diseases, such as metabolic
syndrome (MetS). IL-10 and IL-1β are pleiotropic cytokines with multiple biological effects …