Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling
G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …
GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling
Classically, G protein-coupled receptor (GPCR) stimulation promotes G protein signaling at
the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor …
the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor …
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
TJ Cahill III, ARB Thomsen… - Proceedings of the …, 2017 - National Acad Sciences
β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G
protein signaling, to initiate signaling on their own, and to mediate receptor endocytosis …
protein signaling, to initiate signaling on their own, and to mediate receptor endocytosis …
Conformational biosensors reveal GPCR signalling from endosomes
A long-held tenet of molecular pharmacology is that canonical signal transduction mediated
by G-protein-coupled receptor (GPCR) coupling to heterotrimeric G proteins is confined to …
by G-protein-coupled receptor (GPCR) coupling to heterotrimeric G proteins is confined to …
Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis
G protein–coupled receptors (GPCRs) are well known to signal via cyclic AMP (cAMP)
production at the plasma membrane, but it is now clear that various GPCRs also signal after …
production at the plasma membrane, but it is now clear that various GPCRs also signal after …
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
A brief history of G-protein coupled receptors (Nobel Lecture).
The article presents a lecture on the history of G-protein coupled receptors (GPCRs)
delivered by Professor Robert J. Lefkowitz of Duke University Medical Center in Durham …
delivered by Professor Robert J. Lefkowitz of Duke University Medical Center in Durham …