Bipolar disorders (BDs) are recurrent and sometimes chronic disorders of mood that affect
around 2% of the world's population and encompass a spectrum between severe elevated …

Suicide attempt is generally defined as a self-destructive act carried out with some degree of
intent to end one's life. 1, 2 Suicidal behavior refers to suicide death but also includes …

Importance Major depressive disorder (MDD), a common mental disorder in the US, may
have substantial impact on the lives of affected individuals. If left untreated, MDD can …

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to
treatment. Despite evidence for the efficacy of multimodality interventions, the majority of …

Importance Depression is common and associated with substantial burden. Suicide rates
have increased over the past decade, and both suicide attempts and deaths have …

Suicidal behavior is more prevalent in bipolar disorders than in other psychiatric illnesses. In
the last thirty years evidence has emerged to indicate that long-term treatment of bipolar …

Executive summary By delivering transformative shifts in societal attitudes and initiating a
radical redesign of mental health care, we can fundamentally improve the lives of people …

AimsLithium has long been believed to reduce the risk of suicide and suicidal behaviour in
people with mood disorders. Previous meta-analyses appeared to support this belief, but …

Over the last six decades, lithium has been considered the gold standard treatment for the
long-term management of bipolar disorder due to its efficacy in preventing both manic and …

Aging is a multifactorial biological process involving chronic diseases that manifest from the
molecular level to the systemic level. From its inception to 31 May 2022, this study searched …