Penetration enhancers

AC Williams, BW Barry - Advanced drug delivery reviews, 2012 - Elsevier
One long-standing approach for improving transdermal drug delivery uses penetration
enhancers (also called sorption promoters or accelerants) which penetrate into skin to …

Microemulsions as transdermal drug delivery vehicles

A Kogan, N Garti - Advances in colloid and interface science, 2006 - Elsevier
Microemulsions are clear, stable, isotropic mixtures of oil, water, and surfactant, frequently in
combination with a cosurfactant. Microemulsions have been intensively studied during the …

Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity

DW Lachenmeier - Journal of Occupational Medicine and Toxicology, 2008 - Springer
Ethanol is widely used in all kinds of products with direct exposure to the human skin (eg
medicinal products like hand disinfectants in occupational settings, cosmetics like hairsprays …

Quantitative structure–permeability relationships (QSPRs) for percutaneous absorption

GP Moss, JC Dearden, H Patel, MTD Cronin - Toxicology in vitro, 2002 - Elsevier
Quantitative structure–permeability relationships (QSPRs) have been derived by many
researchers to model the passive, diffusion-controlled, percutaneous penetration of …

Synergistic penetration enhancement effect of ethanol and phospholipids on the topical delivery of cyclosporin A

DD Verma, A Fahr - Journal of controlled release, 2004 - Elsevier
In the present study, ethanol was used with a commercially available lipid mixture, NAT
8539, to improve the topical delivery of cyclosporin A (CyA). The vesicles formed from this …

Skin delivery of 5‐fluorouracil from ultradeformable and standard liposomes in‐vitro

GMME Maghraby, AC Williams… - Journal of Pharmacy …, 2001 - Wiley Online Library
The potential use of ultradeformable and standard liposomes as skin drug delivery systems
was investigated in‐vitro. An improved experimental design gave a good measure for skin …

Tacrolimus-loaded ethosomes: physicochemical characterization and in vivo evaluation

G Li, Y Fan, C Fan, X Li, X Wang, M Li, Y Liu - European journal of …, 2012 - Elsevier
The purpose of this work was to prepare and characterize a novel ethosomal carrier for
tacrolimus, an immunosuppressant treating atopic dermatitis (AD), and to investigate …

Microemulsions as a surrogate carrier for dermal drug delivery

A Azeem, ZI Khan, M Aqil, FJ Ahmad… - Drug development …, 2009 - Taylor & Francis
Microemulsions are isotropic, thermodynamically stable transparent (or translucent) systems
of oil, water, and surfactant, frequently in combination with a cosurfactant with a droplet size …

Innovative strategies for enhancing topical and transdermal drug delivery

DIJ Morrow, PA McCarron, AD Woolfson… - The Open Drug …, 2007 - benthamopen.com
Historically, the skin was thought to be a simple homogenous barrier. However, it is now
known to be a highly specialised organ, and plays a key role in homeostasis. The protective …

Oestradiol permeation through human skin and silastic membrane: effects of propylene glycol and supersaturation

NA Megrab, AC Williams, BW Barry - Journal of controlled release, 1995 - Elsevier
One approach to transdermal permeation enhancement investigated in this paper is to
increase the thermodynamic activity of a drug in the transdermal delivery system to …