What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer's disease, about the therapeutic strategies in Alzheimer's research

M Salkovic-Petrisic, A Knezovic, S Hoyer… - Journal of neural …, 2013 - Springer
Experimental models that faithfully mimic the developmental pathology of sporadic
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …

Streptozotocin intracerebroventricular-induced neurotoxicity and brain insulin resistance: a therapeutic intervention for treatment of sporadic Alzheimer's disease (sAD …

PK Kamat, A Kalani, S Rai, SK Tota, A Kumar… - Molecular …, 2016 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that is remarkably characterized
by pathological hallmarks which include amyloid plaques, neurofibrillary tangles, neuronal …

PDE4 as a target for cognition enhancement

W Richter, FS Menniti, HT Zhang… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: The second messengers cAMP and cGMP mediate fundamental aspects of
brain function relevant to memory, learning, and cognitive functions. Consequently, cyclic …

Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic …

SM Pacheco, MSP Soares, JM Gutierres… - The Journal of …, 2018 - Elsevier
Anthocyanins (ANT) are polyphenolic flavonoids with antioxidant and neuroprotective
properties. This study evaluated the effect of ANT treatment on cognitive performance and …

Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats

R Deshmukh, M Kaundal, V Bansal - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Oxidative stress has been implicated in cognitive decline as seen during normal aging and
in sporadic Alzheimer's disease (AD). Caffeic acid, a polyphenolic compound, has been …

Vitamin D3 attenuates cognitive deficits and neuroinflammatory responses in ICV-STZ induced sporadic Alzheimer's disease

P Yamini, RS Ray, K Chopra - Inflammopharmacology, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
intracellular neurofibrillary tangles and extracellular Aβ deposition. Growing experimental …

Protective effect of andrographolide against STZ induced Alzheimer's disease in experimental rats: possible neuromodulation and Aβ(1–42) analysis

R Patel, K Kaur, S Singh - Inflammopharmacology, 2021 - Springer
STZ is a glucosamine-nitrosourea compound, causes dysfunctioning of insulin receptors in
the brain and disrupts glucose metabolism, produces cognitive decline and AD-like …

Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of …

A Kumar, N Singh - Biomedicine & Pharmacotherapy, 2017 - Elsevier
The study investigates the potential of Rolipram a phosphodiesterase-4 inhibitor in cognitive
deficits induced by streptozotocin (STZ, 3 mg/kg intracerebroventricularly) and natural …

Biophysical, Biochemical, and Behavioral Implications of ApoE3 Conjugated Donepezil Nanomedicine in a Aβ1–42 Induced Alzheimer's Disease Rat Model

KV Krishna, RN Saha, SK Dubey - ACS Chemical Neuroscience, 2020 - ACS Publications
Alzheimer's disease (AD) is a progressive neurological disorder and is the most common
type of dementia. Amyloid β (Aβ) plaques play an important role in the pathophysiology of …

Aurothioglucose encapsulated nanoparticles fostered neuroprotection in streptozotocin-induced Alzheimer's disease

SK Kushawaha, MS Ashawat, D Soni, P Kumar, A Baldi - Brain Research, 2024 - Elsevier
Alzherimer's disease (AD) is an age-dependent ubiquitous ailment worldwide with limited
therapies that only alleviate the symptoms of AD but do not cure them entirely because of the …