Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Amyloid beta: structure, biology and structure-based therapeutic development
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …
Gangliosides in the brain: physiology, pathophysiology and therapeutic applications
Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …
The role of ceramide and sphingosine-1-phosphate in Alzheimer's disease and other neurodegenerative disorders
K Czubowicz, H Jęśko, P Wencel, WJ Lukiw… - Molecular …, 2019 - Springer
Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
Sphingolipids: membrane microdomains in brain development, function and neurological diseases
ASB Olsen, NJ Færgeman - Open biology, 2017 - royalsocietypublishing.org
Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …
of the plasma membranes and are important for proper brain development and functions …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Membrane lipid nanodomains
Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …
sizes and properties. The organization of membrane lipids into nanodomains might …
Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer's disease
V Rudajev, J Novotny - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …
devastating and widespread diseases worldwide, mainly affecting the aging population. One …
GM1 ganglioside is a key factor in maintaining the mammalian neuronal functions avoiding neurodegeneration
Many species of ganglioside GM1, differing for the sialic acid and ceramide content, have
been characterized and their physico-chemical properties have been studied in detail since …
been characterized and their physico-chemical properties have been studied in detail since …
There is no simple model of the plasma membrane organization
Ever since technologies enabled the characterization of eukaryotic plasma membranes,
heterogeneities in the distributions of its constituents were observed. Over the years this led …
heterogeneities in the distributions of its constituents were observed. Over the years this led …