Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …

Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

The EcoCyc model-organism database collects and summarizes experimental data for
Escherichia coli K-12. EcoCyc is regularly updated by the manual curation of individual …

The response to DNA damage is critical for cellular homeostasis, tumor suppression,
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …

BRCA1/2 mutant tumor cells display an elevated mutation burden, the etiology of which
remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous …

Current base editors (BEs) use DNA deaminases, including cytidine deaminase in cytidine
BE (CBE) or adenine deaminase in adenine BE (ABE), to facilitate transition nucleotide …

The replisome quickly and accurately copies billions of DNA bases each cell division cycle.
However, it can make errors, especially when the template DNA is damaged. In these cases …

Base editors (BEs) introduce base substitutions without double-strand DNA cleavage.
Besides precise substitutions, BEs generate low-frequency 'stochastic'byproducts through …

Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype
switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic …

Thousands of apurinic/apyrimidinic (AP or abasic) sites form in each cell, each day. This
simple DNA lesion can have profound consequences to cellular function, genome stability …