Acute ischemic stroke is a common cause of morbidity and mortality worldwide.
Thrombolysis with recombinant tissue plasminogen activator and endovascular …

Numerous studies have documented increases in matrix metalloproteinases (MMPs),
specifically MMP-9 levels following stroke, with such perturbations associated with …

Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Treatments for acute ischaemic stroke continue to evolve after the superior value of
endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately …

Here we show that ischemia induces sustained contraction of pericytes on microvessels in
the intact mouse brain. Pericytes remain contracted despite successful reopening of the …

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to
the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical …

Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

Recanalization and neuroprotection have been mainly targeted for the specific treatment of
acute ischemic stroke. Free radicals play a crucial role in brain ischemic injury by …

Stroke is considered to be an acute cerebrovascular disease, including ischemic stroke and
hemorrhagic stroke. The high incidence and poor prognosis of stroke suggest that it is a …