Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular
barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During …

The vertebrate vasculature displays high organotypic specialization, with the structure and
function of blood vessels catering to the specific needs of each tissue. A unique feature of …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …

Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …

Dengue is the most prevalent arboviral disease in humans and a major public health
problem worldwide. Systemic plasma leakage, leading to hypovolemic shock and potentially …

Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Endothelial cells line the inner portion of the heart, blood vessels, and lymphatic vessels; a
basal membrane of extracellular matrix lines the extraluminal side of endothelial cells. The …