SYNOPSIS (1 paragraph): Parkinson's disease (PD) is a complex age-related
neurodegenerative disease associated with dopamine deficiency and both motor and …

Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Accumulation of neuronal α-synuclein is a prominent feature in Parkinson's disease. More
recently, such abnormal protein aggregation has been reported to spread from cell to cell …

Aggregation of tau into filamentous inclusions underlies Alzheimer's disease (AD) and
numerous other neurodegenerative tauopathies. The pathogenesis of tauopathies remains …

Trace elements and metals play critical roles in the normal functioning of the central nervous
system (CNS), and their dysregulation has been implicated in neurodegenerative disorders …

Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …

Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …

Manganese is an essential trace metal. The dysregulation of manganese seen in a broad
spectrum of neurological disorders reflects its importance in brain development and key …

Neurodegenerative diseases are characterized by neuronal impairment and loss of function,
and with the major shared histopathological hallmarks of misfolding and aggregation of …

Background An unmet clinical need in Parkinson's disease (PD) is to identify biomarkers for
diagnosis, preferably in peripherally accessible tissues such as skin. Immunohistochemical …