Adiponectin, leptin and cardiovascular disorders

S Zhao, CM Kusminski, PE Scherer - Circulation research, 2021 - Am Heart Assoc
The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

Multifaceted physiological roles of adiponectin in inflammation and diseases

HM Choi, HM Doss, KS Kim - International journal of molecular sciences, 2020 - mdpi.com
Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white
adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and …

Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function

E Brennan, P Kantharidis, ME Cooper… - Nature Reviews …, 2021 - nature.com
Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …

Beneficial effects of adiponectin on glucose and lipid metabolism and atherosclerotic progression: mechanisms and perspectives

H Yanai, H Yoshida - International journal of molecular sciences, 2019 - mdpi.com
Circulating adiponectin concentrations are reduced in obese individuals, and this reduction
has been proposed to have a crucial role in the pathogenesis of atherosclerosis and …

[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus

MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

The complex role of adipokines in obesity, inflammation, and autoimmunity

EB Taylor - Clinical Science, 2021 - portlandpress.com
The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Changes in nutritional status impact immune cell metabolism and function

Y Alwarawrah, K Kiernan, NJ MacIver - Frontiers in immunology, 2018 - frontiersin.org
Immune cell function and metabolism are closely linked. Many studies have now clearly
demonstrated that alterations in cellular metabolism influence immune cell function and that …

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

DK Sahoo, RM Heilmann, B Paital, A Patel… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …

The role of infiltrating immune cells in dysfunctional adipose tissue

TJ Guzik, DS Skiba, RM Touyz… - Cardiovascular …, 2017 - academic.oup.com
Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …

Adiponectin, obesity, and cancer: clash of the bigwigs in health and disease

S Parida, S Siddharth, D Sharma - International journal of molecular …, 2019 - mdpi.com
Adiponectin is one of the most important adipocytokines secreted by adipocytes and is
called a “guardian angel adipocytokine” owing to its unique biological functions. Adiponectin …