Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
Bile acid metabolism and signaling, the microbiota, and metabolic disease
The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …
gastrointestinal tract contributes to host health through its role in producing energy or …
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on
signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently …
signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently …
Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease
Bile acids are signaling molecules that coordinately regulate metabolism and inflammation
via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …
via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …
Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism
Bile acids activate farnesoid X receptor (FXR) and G protein–coupled bile acid receptor‐1
(aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and …
(aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and …
[HTML][HTML] Bile acid metabolism in liver pathobiology
Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain
bile acid homeostasis, which is essential for protecting liver and other tissues and cells from …
bile acid homeostasis, which is essential for protecting liver and other tissues and cells from …
Role of bile acids in metabolic control
Bile acids are endocrine molecules that in addition to facilitating the absorption of fat-soluble
nutrients regulate numerous metabolic processes, including glucose, lipid, and energy …
nutrients regulate numerous metabolic processes, including glucose, lipid, and energy …
Gut microbiota: an integral moderator in health and disease
Q Feng, WD Chen, YD Wang - Frontiers in microbiology, 2018 - frontiersin.org
The gut microbiota, as the main member in gut microecology, is an essential mediator in
health and disease. The gut microbiota interacts with various organs and systems in the …
health and disease. The gut microbiota interacts with various organs and systems in the …
Discovery of farnesoid X receptor and its role in bile acid metabolism
In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
Bile acid synthesis is the most significant pathway for catabolism of cholesterol and for
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …
maintenance of whole body cholesterol homeostasis. Bile acids are physiological …