Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

[HTML][HTML] Lipid–protein interactions in biological membranes: a structural perspective

AG Lee - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2003 - Elsevier
Lipid molecules bound to membrane proteins are resolved in some high-resolution
structures of membrane proteins. An analysis of these structures provides a framework …

A computer perspective of membranes: molecular dynamics studies of lipid bilayer systems

DP Tieleman, SJ Marrink, HJC Berendsen - Biochimica et Biophysica Acta …, 1997 - Elsevier
Knowledge of the structure and dynamics of membranes has traditionally been fragmentary
at the atomic level. This is due partly to the fluid character of membranes under physiological …

Texts in Computational Science and Engineering

TJ Barth, M Griebel, DE Keyes, RM Nieminen, D Roose - 2007 - Springer
The rapid development of parallel computing systems made it possible to recreate and
predict physical processes on computers. Nowadays, computer simulations complement …

Setting up and running molecular dynamics simulations of membrane proteins

C Kandt, WL Ash, DP Tieleman - Methods, 2007 - Elsevier
Molecular dynamics simulations have become a popular and powerful technique to study
lipids and membrane proteins. We present some general questions and issues that should …

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications

S Feng, S Park, YK Choi, W Im - Journal of chemical theory and …, 2023 - ACS Publications
Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

Protein, lipid and water organization in bacteriorhodopsin crystals: a molecular view of the purple membrane at 1.9 Å resolution

H Belrhali, P Nollert, A Royant, C Menzel… - Structure, 1999 - cell.com
Abstract Background: Bacteriorhodopsin (bR) from Halobacterium salinarum is a proton
pump that converts the energy of light into a proton gradient that drives ATP synthesis. The …

Bioenergetics of the Archaea

G Schäfer, M Engelhard… - … and molecular biology …, 1999 - Am Soc Microbiol
In the late 1970s, on the basis of rRNA phylogeny, Archaea (archaebacteria) was identified
as a distinct domain of life besides Bacteria (eubacteria) and Eucarya. Though forming a …

A molecular dynamics study of the pores formed by Escherichia coli OmpF porin in a fully hydrated palmitoyloleoylphosphatidylcholine bilayer

DP Tieleman, HJC Berendsen - Biophysical journal, 1998 - cell.com
In this paper we study the properties of pores formed by OmpF porin from Escherichia coli,
based on a molecular dynamics simulation of the OmpF trimer, 318 palmitoyl-oleoyl …

Effective energy function for proteins in lipid membranes

T Lazaridis - Proteins: Structure, Function, and Bioinformatics, 2003 - Wiley Online Library
A simple extension of the EEF1 energy function to heterogeneous membrane‐aqueous
media is proposed. The extension consists of (a) development of solvation parameters for a …