Abstract In 1964, Vincent Allfrey and colleagues reported the identification of histone
acetylation and with deep insight proposed a regulatory role for this protein modification in …

Transcription factor networks have evolved in order to control, coordinate, and separate, the
functions of distinct network modules spatially and temporally. In this review we focus on the …

Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the
molecular and genetic bases of such sex differences are ill-defined and presumptively …

This review is intended to provide a broad outline of the biological and molecular functions
of MYC as well as of the larger protein network within which MYC operates. We present a …

Recent studies on enzymes and reader proteins for histone crotonylation support a function
of histone crotonylation in transcription. However, the enzyme (s) responsible for histone …

Cytosine residues in the sequence 5′ CpG (cytosine–guanine) are often postsynthetically
methylated in animal genomes. CpG methylation is involved in long-term silencing of certain …

Histone acetylation in chromatin structure and transcription | Nature Skip to main content
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The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a
sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be …

), and its biologic significance has emerged. The nucleosome is a focal point of transcription
control, uniting previously disparate observations on gene activation and repression at the …

The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and
anti-inflammatory properties remains challenging in large part owing to the difficulty of …