The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes,
encompassing development, tissue homeostasis, and cell proliferation. Under normal …

The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …

Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

Cancer is a complex disease displaying a variety of cell states and phenotypes. This
diversity, known as cancer cell plasticity, confers cancer cells the ability to change in …

The success of next-generation androgen receptor (AR) pathway inhibitors, such as
abiraterone acetate and enzalutamide, in treating prostate cancer has been hampered by …

During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …

WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …

Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …