Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

T cells orchestrate adaptive immunity against pathogens and other immune challenges, but
their dysfunction can also mediate the pathogenesis of cancer and autoimmunity. Metabolic …

The solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor-
infiltrating T cells (TILs), hallmarked by the inability to maintain effective energy synthesis for …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Nearly 130 years after the first insights into the existence of mitochondria, new
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …

Recent advances in the field of immunometabolism support the concept that fundamental
processes in T cell biology, such as TCR-mediated activation and T helper lineage …