Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

TKH Scheel, CM Rice - Nature medicine, 2013 - nature.com
More than two decades of intense research has provided a detailed understanding of
hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has …

Ligand density on nanoparticles: A parameter with critical impact on nanomedicine

AM Alkilany, L Zhu, H Weller, A Mews, WJ Parak… - Advanced drug delivery …, 2019 - Elsevier
Nanoparticles modified with ligands for specific targeting towards receptors expressed on
the surface of target cells are discussed in literature towards improved delivery strategies. In …

[HTML][HTML] Virology and cell biology of the hepatitis C virus life cycle–An update

J Dubuisson, FL Cosset - Journal of hepatology, 2014 - Elsevier
Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

The ins and outs of hepatitis C virus entry and assembly

BD Lindenbach, CM Rice - Nature Reviews Microbiology, 2013 - nature.com
Hepatitis C virus, a major human pathogen, produces infectious virus particles with several
unique features, such as an ability to interact with serum lipoproteins, a dizzyingly …

[HTML][HTML] Multifaceted roles for lipids in viral infection

NS Heaton, G Randall - Trends in microbiology, 2011 - cell.com
Viruses have evolved complex and dynamic interactions with their host cell. In recent years
we have gained insight into the expanding roles for host lipids in the virus life cycle. In …

Ultrastructural analysis of hepatitis C virus particles

MT Catanese, K Uryu, M Kopp, TJ Edwards… - Proceedings of the …, 2013 - pnas.org
Hepatitis C virus (HCV) is a major cause of chronic liver disease, with an estimated 170
million people infected worldwide. Low yields, poor stability, and inefficient binding to …

[HTML][HTML] Assembly of infectious hepatitis C virus particles

R Bartenschlager, F Penin, V Lohmann, P André - Trends in microbiology, 2011 - cell.com
A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid
synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious …

The role of host cholesterol during flavivirus infection

JF Osuna-Ramos, JM Reyes-Ruiz… - Frontiers in cellular and …, 2018 - frontiersin.org
In recent years the emergence and resurgence of arboviruses have generated a global
health alert. Among arboviruses, Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and …

Hepatitis C virus RNA replication and assembly: living on the fat of the land

D Paul, V Madan, R Bartenschlager - Cell host & microbe, 2014 - cell.com
Hepatitis C virus (HCV) is a major global health burden accounting for around 170 million
chronic infections worldwide. Although highly potent direct-acting antiviral drugs to treat …

Role of lipids in virus replication

M Lorizate, HG Kräusslich - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Viruses intricately interact with and modulate cellular membranes at several stages of their
replication, but much less is known about the role of viral lipids compared to proteins and …