The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

The aim of this critical review is to provide a broad but digestible overview of
mechanochemical synthesis, ie reactions conducted by grinding solid reactants together …

Mechanochemical reactions effected by milling or grinding are an attractive means to
conduct chemical reactions dependent on molecular recognition and to systematically …

A brief and systematic overview of recent advances in understanding the mechanism of
mechanochemical cocrystallization at macroscopic (bulk phase transformations) and …

This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

The preparation of co-crystals via mechanochemistry combines the quest for clean and
green processes with the investigation of multicomponent new materials, among the …

Mechanochemical liquid-assisted grinding (LAG) and sonochemical (SonicSlurry)
techniques have been compared as methods to construct four model pharmaceutical …

Avoiding the use of solvents in synthesis can reduce environmental contamination and even
be more convenient than using solvent-based synthesis. In this tutorial review we focus on …

Control of the solid-state arrangement of molecules within a crystal is a central challenge for
organic materials chemistry. In the context of solid pharmaceuticals, addressing this …

We provide a brief overview of recent advances in the use of mechanochemical techniques
for the synthesis of organic molecules and materials, highlighting selected examples of …