Tetrahydrobiopterin (BH4) is an endogenous cofactor for various enzymatic conversions of
essential biomolecules including nitric oxide, tyrosine, dopamine, serotonin and …

Objective The purpose of this article is to review and integrate the available literature in
different fields to gain a better understanding of the basic physiology and optimize vascular …

Efficacy of ischemic preconditioning is decreased in animal models of type 2 diabetes
mellitus while the responses in humans with diabetes are contradictory. It is unknown …

The eukaryotic initiation factor 3f (eIF3f) is the p47 subunit of the multi-subunit eIF3 complex.
eIF3 plays an important role in translation initiation. In the present study, we investigate the …

Endothelial nitric oxide synthase (eNOS) monomerization and uncoupling play crucial roles
in mediating vascular dysfunction in diabetes, although the underlying mechanisms are still …

It is of great importance to protect the brain against cerebral ischemia and reperfusion (I/R)
injury, which leads to excitotoxicity, redox imbalance, inflammation and apoptosis; however …

Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …

Background—Diabetic heart disease is associated with tetrahydrobiopterin oxidation and
high arginase activity, leading to endothelial nitric oxide synthase dysfunction. Sepiapterin …

Preeclampsia (PE), gestational diabetes mellitus (GDM), and maternal supraphysiological
hypercholesterolaemia (MSPH) are pregnancy-related conditions that cause metabolic …

The role of microRNA-1 (miR-1) in ischemia/reperfusion (I/R)-induced injury is not well
illustrated. The present study aimed to investigate the expression and potential target of miR …