[HTML][HTML] SARS-CoV-2 variants, spike mutations and immune escape
Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) genome are expected to be either deleterious and swiftly purged or relatively …
CoV-2) genome are expected to be either deleterious and swiftly purged or relatively …
[HTML][HTML] Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19
Coronavirus belongs to the family of Coronaviridae, comprising single-stranded, positive-
sense RNA genome (+ ssRNA) of around 26 to 32 kilobases, and has been known to cause …
sense RNA genome (+ ssRNA) of around 26 to 32 kilobases, and has been known to cause …
[HTML][HTML] Molecular architecture of the SARS-CoV-2 virus
SARS-CoV-2 is an enveloped virus responsible for the COVID-19 pandemic. Despite recent
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite
Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally
target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral …
target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral …
High-resolution native mass spectrometry
Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
On scientific understanding with artificial intelligence
An oracle that correctly predicts the outcome of every particle physics experiment, the
products of every possible chemical reaction or the function of every protein would …
products of every possible chemical reaction or the function of every protein would …
A glycan gate controls opening of the SARS-CoV-2 spike protein
SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding
domain (RBD), which transitions from a glycan-shielded 'down'to an exposed 'up'state to …
domain (RBD), which transitions from a glycan-shielded 'down'to an exposed 'up'state to …
Spike deep mutational scanning helps predict success of SARS-CoV-2 clades
B Dadonaite, J Brown, TE McMahon, AG Farrell… - Nature, 2024 - nature.com
SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …
The glycosylation in SARS-CoV-2 and its receptor ACE2
Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …
Role of oxidative stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) infection: a review
Abstract Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic
and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several …
and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several …