Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …

Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial
oligonucleotide libraries through the well-known in vitro selection and iteration process …

Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific
targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution …

Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and
are commonly produced by systematic evolution of ligands by exponential enrichment …

Recent advances of biological drugs have broadened the scope of therapeutic targets for a
variety of human diseases. This holds true for dozens of RNA-based therapeutics currently …

Aptamers and SELEX (systematic evolution of ligands by exponential enrichment)
technology have gained increasing attention over the past 25 years. Despite their functional …

Aptamer nanomedicine, including therapeutic aptamers and aptamer nanocomplexes, is
beginning to fulfill its potential in both clinical trials and preclinical studies. Especially in …

RNA aptamers can fold into complex structures and bind with high affinity and selectivity to
various macromolecules, viruses, and cells. They are isolated from a large pool of nucleic …

This review is intended to guide the novice in aptamer research and development to
understand virtually all of the aptamer development options and currently available assay …

This article focuses on new antithrombotic drugs that are in or are entering phase 3 clinical
testing. Development of these new agents was prompted by the limitations of existing …