Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Injectable hydrogels are one of the most widely investigated and versatile technologies for
drug delivery and tissue engineering applications. Hydrogels' versatility arises from their …

Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

Although only a few stem cell-based therapies are currently available to patients, stem cells
hold tremendous regenerative potential, and several exciting clinical applications are on the …

Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

Transplantation of mesenchymal stem cells (MSCs) holds promise to repair severe traumatic
injuries. However, current transplantation practices limit the potential of this technique, either …

Over 90% of potential anti-cancer drug candidates results in translational failures in clinical
trials. The main reason for this failure can be attributed to the non-accurate pre-clinical …

The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …