Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune
response and have been used since decades to treat various inflammatory and autoimmune …

Stress-induced mental health disorders are affecting many people around the world.
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …

Aging and psychosocial stress are associated with increased inflammation and disease risk,
but the underlying molecular mechanisms are unclear. Because both aging and stress are …

The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress
responses in mammals and as a potential therapeutic target for stress-related disorders …

HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as
HSP90beta, is a member of the large family of HSPs which function as molecular …

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …

In this article we summarize the birth of the field of nuclear receptors, the discovery of
untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic of severe coronavirus disease 2019 (COVID-19). Staphylococcus aureus is …

Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-
isomerase domain. High molecular weight immunophilins are characterized by the …

Mutual regulation and balance between the endocrine and immune systems facilitate an
organism's stress response and are impaired following chronic stress or prolonged immune …