Target identification of small molecules based on chemical biology approaches
Y Futamura, M Muroi, H Osada - Molecular BioSystems, 2013 - pubs.rsc.org
Recently, a phenotypic approach—screens that assess the effects of compounds on cells,
tissues, or whole organisms—has been reconsidered and reintroduced as a complementary …
tissues, or whole organisms—has been reconsidered and reintroduced as a complementary …
The phosphate ester group in secondary metabolites
Covering: 2000 to mid-2021 The phosphate ester is a versatile, widespread functional group
involved in a plethora of biological activities. Its presence in secondary metabolites …
involved in a plethora of biological activities. Its presence in secondary metabolites …
Plant-derived antifungal agent poacic acid targets β-1, 3-glucan
A rise in resistance to current antifungals necessitates strategies to identify alternative
sources of effective fungicides. We report the discovery of poacic acid, a potent antifungal …
sources of effective fungicides. We report the discovery of poacic acid, a potent antifungal …
Vanillin Inhibits Translation and Induces Messenger Ribonucleoprotein (mRNP) Granule Formation in Saccharomyces cerevisiae: Application and Validation of High …
Vanillin, generated by acid hydrolysis of lignocellulose, acts as a potent inhibitor of the
growth of the yeast Saccharomyces cerevisiae. Here, we investigated the cellular processes …
growth of the yeast Saccharomyces cerevisiae. Here, we investigated the cellular processes …
Defining Functions of Mannoproteins in Saccharomyces cerevisiae by High-Dimensional Morphological Phenoty**
Mannoproteins are non-filamentous glycoproteins localized to the outermost layer of the
yeast cell wall. The physiological roles of these structural components have not been …
yeast cell wall. The physiological roles of these structural components have not been …
Targeted mutations produce divergent characteristics in pedigreed sake yeast strains
N Klinkaewboonwong, S Ohnuki, T Chadani, I Nishida… - Microorganisms, 2023 - mdpi.com
Modification of the genetic background and, in some cases, the introduction of targeted
mutations can play a critical role in producing trait characteristics during the breeding of …
mutations can play a critical role in producing trait characteristics during the breeding of …
[HTML][HTML] Image analysis in microbiology: a review
E Puchkov - Journal of Computer and Communications, 2016 - scirp.org
This review is focused on using computer image analysis as a means of objective and
quantitative characterizing optical images of the macroscopic (eg microbial colonies) and …
quantitative characterizing optical images of the macroscopic (eg microbial colonies) and …
High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds
Morphological profiling is an omics-based approach for predicting intracellular targets of
chemical compounds in which the dose-dependent morphological changes induced by the …
chemical compounds in which the dose-dependent morphological changes induced by the …
Distinct roles of cell wall biogenesis in yeast morphogenesis as revealed by multivariate analysis of high-dimensional morphometric data
The cell wall of budding yeast is a rigid structure composed of multiple components. To
thoroughly understand its involvement in morphogenesis, we used the image analysis …
thoroughly understand its involvement in morphogenesis, we used the image analysis …
Phenotypic diagnosis of lineage and differentiation during sake yeast breeding
Sake yeast was developed exclusively in Japan. Its diversification during breeding remains
largely uncharacterized. To evaluate the breeding processes of the sake lineage, we …
largely uncharacterized. To evaluate the breeding processes of the sake lineage, we …