Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments

SJ Yong - Infectious diseases, 2021 - Taylor & Francis
Long COVID or post-COVID-19 syndrome first gained widespread recognition among social
support groups and later in scientific and medical communities. This illness is poorly …

Long COVID: major findings, mechanisms and recommendations

HE Davis, L McCorkell, JM Vogel… - Nature Reviews …, 2023 - nature.com
Long COVID is an often debilitating illness that occurs in at least 10% of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms …

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration

L Zhang, L Zhou, L Bao, J Liu, H Zhu, Q Lv… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …

Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

KKW To, S Sridhar, KHY Chiu, DLL Hung… - Emerging microbes & …, 2021 - Taylor & Francis
Without modern medical management and vaccines, the severity of the Coronavirus
Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) …

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

L Bauer, BM Laksono, FMS de Vrij, SA Kushner… - Trends in …, 2022 - cell.com
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with
a diverse spectrum of neurological complications during the acute and postacute stages …

Cognitive impact of COVID-19: looking beyond the short term

S Miners, PG Kehoe, S Love - Alzheimer's research & therapy, 2020 - Springer
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

The neurological manifestations of post-acute sequelae of SARS-CoV-2 infection

N Moghimi, M Di Napoli, J Biller, JE Siegler… - Current Neurology and …, 2021 - Springer
Abstract Purpose of Review Coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health challenge. This …

Persistent brainstem dysfunction in long-COVID: a hypothesis

SJ Yong - ACS chemical neuroscience, 2021 - ACS Publications
Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial
disease severity or age. Symptoms of long-COVID include fatigue, dyspnea, gastrointestinal …

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

F Crunfli, VC Carregari, FP Veras… - Proceedings of the …, 2022 - National Acad Sciences
Although increasing evidence confirms neuropsychiatric manifestations associated mainly
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …

ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response

C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen… - Cell stem cell, 2021 - cell.com
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …