Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation

I Lingvay, P Sumithran, RV Cohen, CW le Roux - The Lancet, 2022 - thelancet.com
Obesity is now recognised as a disease that is associated with serious morbidity and
increased mortality. One of its main metabolic complications is type 2 diabetes, as the two …

[HTML][HTML] Global pandemics interconnected—obesity, impaired metabolic health and COVID-19

N Stefan, AL Birkenfeld, MB Schulze - Nature Reviews Endocrinology, 2021 - nature.com
Obesity and impaired metabolic health are established risk factors for the non-
communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Metabolically healthy obesity

M Blüher - Endocrine reviews, 2020 - academic.oup.com
Obesity contributes to reduced life expectancy, impaired quality of life, and disabilities,
mainly in those individuals who develop cardiovascular diseases, type 2 diabetes …

Global burden of hematologic malignancies and evolution patterns over the past 30 years

N Zhang, J Wu, Q Wang, Y Liang, X Li, G Chen… - Blood Cancer …, 2023 - nature.com
Hematologic malignancies are among the most common cancers, and understanding their
incidence and death is crucial for targeting prevention, clinical practice improvement, and …

Causes, consequences, and treatment of metabolically unhealthy fat distribution

N Stefan - The lancet Diabetes & endocrinology, 2020 - thelancet.com
An increase in fat mass is considered to be an important risk factor for the worldwide
increase in type 2 diabetes and cardiovascular disease. However, for a given fat mass, there …

Adiponectin, leptin and cardiovascular disorders

S Zhao, CM Kusminski, PE Scherer - Circulation research, 2021 - Am Heart Assoc
The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

Metabolic health and cardiometabolic risk clusters: implications for prediction, prevention, and treatment

N Stefan, MB Schulze - The lancet Diabetes & endocrinology, 2023 - thelancet.com
Among 20 leading global risk factors for years of life lost in 2040, reference forecasts point to
three metabolic risks—high blood pressure, high BMI, and high fasting plasma glucose—as …

Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications

MB Schulze, N Stefan - Nature Reviews Endocrinology, 2024 - nature.com
The concept of metabolic health, particularly in obesity, has attracted a lot of attention in the
scientific community, and is being increasingly used to determine the risk of cardiovascular …

The science of obesity management: an endocrine society scientific statement

GA Bray, WE Heisel, A Afshin, MD Jensen… - Endocrine …, 2018 - academic.oup.com
The prevalence of obesity, measured by body mass index, has risen to unacceptable levels
in both men and women in the United States and worldwide with resultant hazardous health …