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Discovery of urinary biomarkers
A myriad of proteins and peptides can be identified in normal human urine. These are
derived from a variety of sources including glomerular filtration of blood plasma, cell …
derived from a variety of sources including glomerular filtration of blood plasma, cell …
Physiological conditions can be reflected in human urine proteome and metabolome
J Wu, Y Gao - Expert review of proteomics, 2015 - Taylor & Francis
Biomarkers are the measurable changes associated with physiological or
pathophysiological processes. Urine, unlike blood, lacks mechanisms for maintaining …
pathophysiological processes. Urine, unlike blood, lacks mechanisms for maintaining …
Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease
Because of its availability, ease of collection, and correlation with physiology and pathology,
urine is an attractive source for clinical proteomics/peptidomics. However, the lack of …
urine is an attractive source for clinical proteomics/peptidomics. However, the lack of …
Current state of the art for enhancing urine biomarker discovery
M Harpole, J Davis, V Espina - Expert review of Proteomics, 2016 - Taylor & Francis
Introduction: Urine is a highly desirable biospecimen for biomarker analysis because it can
be collected recurrently by non-invasive techniques, in relatively large volumes. Urine …
be collected recurrently by non-invasive techniques, in relatively large volumes. Urine …
Advances in urinary proteome analysis and biomarker discovery
D Fliser, J Novak, V Thongboonkerd… - Journal of the …, 2007 - journals.lww.com
Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still
challenges in clinical nephrology. Definition of biomarkers on the basis of proteome …
challenges in clinical nephrology. Definition of biomarkers on the basis of proteome …
A comprehensive map of the human urinary proteome
The study of the human urinary proteome has the potential to offer significant insights into
normal physiology as well as disease pathology. The information obtained from such studies …
normal physiology as well as disease pathology. The information obtained from such studies …
CE‐MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics
Owing to its availability, ease of collection, and correlation with pathophysiology of diseases,
urine is an attractive source for clinical proteomics. However, many proteomic studies have …
urine is an attractive source for clinical proteomics. However, many proteomic studies have …
Practical points in urinary proteomics
V Thongboonkerd - Journal of proteome research, 2007 - ACS Publications
During the proteomic era, one of the most rapidly growing areas in biomedical research is
biomarker discovery, particularly using proteomic technologies. Urinary proteomics has …
biomarker discovery, particularly using proteomic technologies. Urinary proteomics has …
Biomarker discovery by CE‐MS enables sequence analysis via MS/MS with platform‐independent separation
CE‐MS is a successful proteomic platform for the definition of biomarkers in different body
fluids. Besides the biomarker defining experimental parameters, CE migration time and …
fluids. Besides the biomarker defining experimental parameters, CE migration time and …
Exploring the hidden human urinary proteome via ligand library beads
A Castagna, D Cecconi, L Sennels… - Journal of proteome …, 2005 - ACS Publications
The human urinary proteome has been reassessed and re-evaluated via a novel
concentration/equalization technique, exploiting beads coated with hexameric peptide …
concentration/equalization technique, exploiting beads coated with hexameric peptide …