Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

G Cutillo, AH Saariaho, S Meri - Cellular & molecular immunology, 2020 - nature.com
Gangliosides are structurally and functionally polymorphic sialic acid containing
glycosphingolipids that are widely distributed in the human body. They play important roles …

[HTML][HTML] Neurodegenerative disease: models, mechanisms, and a new hope

AD Gitler, P Dhillon, J Shorter - Disease models & …, 2017 - journals.biologists.com
Neurodegeneration is a feature of many debilitating, incurable diseases that are rapidly
rising in prevalence, such as Parkinson's disease. There is an urgent need to develop new …

Development and in vitro differentiation of Schwann cells

SJ Hörner, N Couturier, DC Gueiber, M Hafner… - Cells, 2022 - mdpi.com
Schwann cells are glial cells of the peripheral nervous system. They exist in several
subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are …

Models and methods to study Schwann cells

S Negro, M Pirazzini, M Rigoni - Journal of Anatomy, 2022 - Wiley Online Library
Schwann cells (SCs) are fundamental components of the peripheral nervous system (PNS)
of all vertebrates and play essential roles in development, maintenance, function, and …

Pancreatic Schwann cell reprogramming supports cancer‐associated neuronal remodeling

MM Rangel‐Sosa, F Mann, S Chauvet - Glia, 2024 - Wiley Online Library
The peripheral nervous system is a key regulator of cancer progression. In pancreatic ductal
adenocarcinoma (PDAC), the sympathetic branch of the autonomic nervous system inhibits …

Lysophosphatidic acid activates satellite glia cells and Schwann cells

JW Robering, L Gebhardt, K Wolf, H Kühn, AE Kremer… - Glia, 2019 - Wiley Online Library
Pruritus is a common and disabling symptom in patients with hepatobiliary disorders,
particularly in those with cholestatic features. Serum levels of lysophosphatidic acid (LPA) …

Purinergic signaling in peripheral nervous system glial cells

J Patritti‐Cram, RA Coover, MP Jankowski, N Ratner - Glia, 2021 - Wiley Online Library
To facilitate analyses of purinergic signaling in peripheral nerve glia, we review recent
literature and catalog purinergic receptor mRNA expression in cultured mouse Schwann …

Neuronal activity-dependent ATP enhances the pro-growth effect of repair Schwann cell extracellular vesicles by increasing their miRNA-21 loading

C Saquel, RJ Catalan, R Lopez-Leal… - Frontiers in Cellular …, 2022 - frontiersin.org
Functional recovery after peripheral nerve injuries is critically dependent on axonal
regeneration. Several autonomous and non-cell autonomous processes regulate axonal …

Purinergic receptors in neurological diseases with motor symptoms: targets for therapy

Á Oliveira-Giacomelli, Y Naaldijk… - Frontiers in …, 2018 - frontiersin.org
Since proving adenosine triphosphate (ATP) functions as a neurotransmitter in neuron/glia
interactions, the purinergic system has been more intensely studied within the scope of the …

Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression

BGS Rocha, CC Picoli, BOP Gonçalves, WN Silva… - Angiogenesis, 2023 - Springer
Cancer cells are embedded within the tissue and interact dynamically with its components
during cancer progression. Understanding the contribution of cellular components within the …