Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …

Women have more body fat than men, but in contrast to the deleterious metabolic
consequences of the central obesity typical of men, the pear-shaped body fat distribution of …

We previously described a DNA methylation (DNAm) based biomarker of human mortality
risk DNAm GrimAge. Here we describe version 2 of GrimAge (trained on individuals aged …

Following the discovery of leptin in 1994, the scientific and clinical communities have held
great hope that manipulation of the leptin axis may lead to the successful treatment of …

Because leptin reduces food intake and body weight, the coexistence of elevated leptin
levels with obesity is widely interpreted as evidence of 'leptin resistance.'Indeed, obesity …

There are fundamental aspects of the control of metabolic homeostasis that are regulated
differently in males and females. This sex asymmetry represents an evolutionary paradigm …

Feeding behavior is critical for survival. In addition to providing all of the body's
macronutrients (carbohydrates, lipids, and proteins) and most micronutrients (minerals and …

Leptin is a hormone secreted by adipose tissue in direct proportion to amount of body fat.
The circulating leptin levels serve as a gauge of energy stores, thereby directing the …