Haemonchus contortus (Barber's pole worm or “BPW”) is the nematode “nemesis” of small
ruminant production systems in tropical and subtropical regions of the world. Its reputation …

Xenobiotic-metabolizing enzymes (XMEs) modulate the biological activity and behavior of
many drugs, including anthelmintics. The effects of anthelmintics can often be abolished by …

Parasitic nematodes are a major threat to global food security, particularly as the world
amasses 10 billion people amid limited arable land,,–. Most traditional nematicides have …

We have undertaken a detailed analysis of the biotransformation of five of the most
therapeutically important benzimidazole anthelmintics-albendazole (ABZ), mebendazole …

Root-knot nematodes (Meloidogyne spp.) are notorious plant-parasitic nematodes that affect
agricultural crops. These obligate soil-dwelling parasites typically maneuver the host plant …

The most important and broad-spectrum drug used to control the parasitic worms to date is
ivermectin (IVM). Resistance against IVM has emerged in parasites, and preserving its …

Resistance to the anthelmintic macrocyclic lactone ivermectin (IVM) has a great impact on
the control of parasitic nematodes. The mechanisms by which nematodes adapt to IVM …

The ascarids are a large group of parasitic nematodes that infect a wide range of animal
species. In humans, they cause neglected diseases of poverty; many animal parasites also …

Anthelmintic resistance (AR) in parasitic nematodes poses a global health problem in
livestock and domestic animals and is an emerging problem in humans. Consequently, we …

The objective of this study was to analyze the mRNA transcription levels of ten functional
genes of P-glycoproteins (P-gp) in free life stages, eggs and infective larvae (L 3) and in …