Phase separation as a missing mechanism for interpretation of disease mutations
It is unclear how disease mutations impact intrinsically disordered protein regions (IDRs),
which lack a stable folded structure. These mutations, while prevalent in disease, are …
which lack a stable folded structure. These mutations, while prevalent in disease, are …
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
[HTML][HTML] Glycogen accumulation and phase separation drives liver tumor initiation
Q Liu, J Li, W Zhang, C **ao, S Zhang, C Nian, J Li… - Cell, 2021 - cell.com
Glucose consumption is generally increased in tumor cells to support tumor growth.
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …
Synthetic protein condensates for cellular and metabolic engineering
Protein condensates are distinct structures assembled in living cells that concentrate
molecules via phase separation in a confined subcellular compartment. In the past decade …
molecules via phase separation in a confined subcellular compartment. In the past decade …
Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses
RNA viruses induce the formation of subcellular organelles that provide microenvironments
conducive to their replication. Here we show that replication factories of rotaviruses …
conducive to their replication. Here we show that replication factories of rotaviruses …
Recent developments in the field of intrinsically disordered proteins: intrinsic disorder–based emergence in cellular biology in light of the physiological and …
VN Uversky - Annual Review of Biophysics, 2021 - annualreviews.org
This review deals with two important concepts—protein intrinsic disorder and proteinaceous
membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific …
membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific …
Liquid-liquid phase separation in neuronal development and synaptic signaling
Formation of biomolecular condensates that are not enclosed by membranes via liquid-
liquid phase separation (LLPS) is a general strategy that cells adopt to organize …
liquid phase separation (LLPS) is a general strategy that cells adopt to organize …
Plants use molecular mechanisms mediated by biomolecular condensates to integrate environmental cues with development
This review highlights recent literature on biomolecular condensates in plant development
and discusses challenges for fully dissecting their functional roles. Plant developmental …
and discusses challenges for fully dissecting their functional roles. Plant developmental …
Essence determines phenomenon: assaying the material properties of biological condensates
Intracellular spaces are partitioned into separate compartments to ensure that numerous
biochemical reactions and cellular functions take place in a spatiotemporally controlled …
biochemical reactions and cellular functions take place in a spatiotemporally controlled …