Beneath the skin: a review of current trends and future prospects of transdermal drug delivery systems

AZ Alkilani, J Nasereddin, R Hamed, S Nimrawi… - Pharmaceutics, 2022 - mdpi.com
The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms
but is as convenient and easy to use for the patient as oral solid dosage forms. In recent …

[HTML][HTML] Solid implantable devices for sustained drug delivery

E Magill, S Demartis, E Gavini, AD Permana… - Advanced Drug Delivery …, 2023 - Elsevier
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …

[HTML][HTML] Long-acting microneedle formulations

LK Vora, AH Sabri, Y Naser, A Himawan… - Advanced Drug Delivery …, 2023 - Elsevier
The minimally-invasive and painless nature of microneedle (MN) application has enabled
the technology to obviate many issues with injectable drug delivery. MNs not only administer …

Reactive oxygen species-responsive gel-based microneedle patches for prolonged and intelligent psoriasis management

D Bi, F Qu, W **ao, J Wu, P Liu, H Du, Y **e, H Liu… - ACS …, 2023 - ACS Publications
Psoriasis is an inflammatory skin disease. Microneedle (MN) patches can improve psoriasis
treatment outcomes by increasing local drug content in the skin. As psoriasis frequently …

Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023 - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

[HTML][HTML] Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer

H Abd-El-Azim, IA Tekko, A Ali, A Ramadan… - Journal of Controlled …, 2022 - Elsevier
Photodynamic therapy (PDT) to manage non-melanoma skin cancers has garnered great
attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with …

Hyaluronic acid-based CuS nanoenzyme biodegradable microneedles for treating deep cutaneous fungal infection without drug resistance

B Wang, W Zhang, Q Pan, J Tao, S Li, T Jiang… - Nano …, 2023 - ACS Publications
Deep cutaneous fungal infection (DCFI) is difficult to be treated by the traditional topical
application due to low drug transdermal efficiency, poor fungicidal effect, and easy to …

Microneedles as a momentous platform for psoriasis therapy and diagnosis: A state-of-the-art review

BHJ Gowda, MG Ahmed, U Hani, P Kesharwani… - International Journal of …, 2023 - Elsevier
Psoriasis is a chronic, autoimmune, and non-communicable skin disease with a worldwide
prevalence rate of 2–3%, creating an economic burden on global health. Some significant …

Microneedle-mediated transdermal delivery of biopharmaceuticals

HX Nguyen, CN Nguyen - Pharmaceutics, 2023 - mdpi.com
Transdermal delivery provides numerous benefits over conventional routes of
administration. However, this strategy is generally limited to a few molecules with specific …

[HTML][HTML] Liposome-loaded polymeric microneedles for enhanced skin deposition of rifampicin

QK Anjani, AK Pandya, S Demartis… - International Journal of …, 2023 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) is a prevailing bacterial pathogen
linked to superficial skin and soft tissue infections (SSTIs). Rifampicin (RIF), a potent …