Cerebral hemorrhage: pathophysiology, treatment, and future directions
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and
mortality. This review article focuses on the epidemiology, cause, mechanisms of injury …
mortality. This review article focuses on the epidemiology, cause, mechanisms of injury …
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
Sex differences in Alzheimer disease—the gateway to precision medicine
Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural
syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic …
syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic …
Alzheimer's pathogenic mechanisms and underlying sex difference
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
women than men: almost two-thirds of patients with AD are women. One prevailing view is …
Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …
[HTML][HTML] Apolipoprotein E in lipid metabolism and neurodegenerative disease
LG Yang, ZM March, RA Stephenson… - Trends in Endocrinology & …, 2023 - cell.com
Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …
APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer's disease: a systematic review
S Emrani, HA Arain, C DeMarshall, T Nuriel - Alzheimer's research & …, 2020 - Springer
Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …
Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease
Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
Background Clearance at the blood-brain barrier (BBB) plays an important role in removal of
Alzheimer's amyloid-β (Aβ) toxin from brain both in humans and animal models …
Alzheimer's amyloid-β (Aβ) toxin from brain both in humans and animal models …
The development and convergence of co-pathologies in Alzheimer's disease
JL Robinson, H Richardson, SX **e, ER Suh… - Brain, 2021 - academic.oup.com
Cerebral amyloid angiopathy (CAA), limbic-predominant age-related TDP-43
encephalopathy neuropathological change (LATE-NC) and Lewy bodies occur in the …
encephalopathy neuropathological change (LATE-NC) and Lewy bodies occur in the …