Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Q Guo, Y Wang, D Xu, J Nossent, NJ Pavlos, J Xu - Bone research, 2018 - nature.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

S Liu, H Ma, H Zhang, C Deng, P **n - Clinical Immunology, 2021 - Elsevier
Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction
in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the …

Effects of targeted therapies on bone in rheumatic and musculoskeletal diseases

B Soós, Á Szentpétery, HG Raterman… - Nature Reviews …, 2022 - nature.com
Generalized bone loss (osteoporosis) and fragility fractures can occur in rheumatic and
musculoskeletal diseases including rheumatoid arthritis and spondyloarthritis (SpA; …

Osteoimmunology: the crosstalk between T cells, B cells, and osteoclasts in rheumatoid arthritis

M Yang, L Zhu - International Journal of Molecular Sciences, 2024 - mdpi.com
Rheumatoid arthritis (RA) is an ongoing inflammatory condition that affects the joints and
can lead to severe damage to cartilage and bones, resulting in significant disability. This …

Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying …

T Takeuchi, Y Tanaka, S Soen, H Yamanaka… - Annals of the rheumatic …, 2019 - Elsevier
Objective To evaluate the efficacy of denosumab in suppressing joint destruction when
added to conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy …

Baricitinib improves bone properties and biomechanics in patients with rheumatoid arthritis: Results of the prospective interventional BARE BONE trial

D Simon, I Minopoulou, S Kemenes… - Arthritis & …, 2023 - Wiley Online Library
Objective Rheumatoid arthritis (RA) is characterized by erosive joint damage, deterioration
of bone mass, and biomechanics. Preclinical evidence suggests a beneficial effect of Janus …

Bone erosions in rheumatoid arthritis: recent developments in pathogenesis and therapeutic implications

PK Panagopoulos, GI Lambrou - Journal of musculoskeletal & …, 2018 - pmc.ncbi.nlm.nih.gov
Bone erosions develop early in the course of rheumatoid arthritis (RA) and deteriorate
progressively, causing joint damage and resulting in impaired functional capacity of patients …

High-resolution peripheral quantitative computed tomography for bone evaluation in inflammatory rheumatic disease

R Klose-Jensen, JJ Tse, KK Keller, C Barnabe… - Frontiers in …, 2020 - frontiersin.org
High resolution peripheral quantitative computed tomography (HR-pQCT) is a 3-
dimensional imaging modality with superior sensitivity for bone changes and abnormalities …

Imaging in inflammatory arthritis: progress towards precision medicine

I Minopoulou, A Kleyer, M Yalcin-Mutlu… - Nature Reviews …, 2023 - nature.com
Imaging techniques such as ultrasonography and MRI have gained ground in the diagnosis
and management of inflammatory arthritis, as these imaging modalities allow a sensitive …

Imaging in rheumatoid arthritis: the role of magnetic resonance imaging and computed tomography

M Østergaard, M Boesen - La radiologia medica, 2019 - Springer
In suspected and diagnosed rheumatoid arthritis (RA), magnetic resonance imaging (MRI)
allows detection of all relevant pathologies, such as synovitis, tenosynovitis, bone marrow …