APT‐weighted MRI: techniques, current neuro applications, and challenging issues

J Zhou, HY Heo, L Knutsson… - Journal of Magnetic …, 2019‏ - Wiley Online Library
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that
generates image contrast based predominantly on the amide protons in mobile cellular …

Magnetization transfer contrast and chemical exchange saturation transfer MRI. Features and analysis of the field-dependent saturation spectrum

PCM Van Zijl, WW Lam, J Xu, L Knutsson, GJ Stanisz - Neuroimage, 2018‏ - Elsevier
Abstract Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation
Transfer (CEST) experiments measure the transfer of magnetization from molecular protons …

Clinical applications of chemical exchange saturation transfer (CEST) MRI

KM Jones, AC Pollard, MD Pagel - Journal of Magnetic …, 2018‏ - Wiley Online Library
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
been developed and employed in multiple clinical imaging research centers worldwide …

Chemical exchange saturation transfer (CEST): what is in a name and what isn't?

PCM Van Zijl, NN Yadav - Magnetic resonance in medicine, 2011‏ - Wiley Online Library
Chemical exchange saturation transfer (CEST) imaging is a relatively new magnetic
resonance imaging contrast approach in which exogenous or endogenous compounds …

Magnetic resonance imaging of glutamate

K Cai, M Haris, A Singh, F Kogan, JH Greenberg… - Nature medicine, 2012‏ - nature.com
Glutamate, a major neurotransmitter in the brain, shows a pH-and concentration-dependent
chemical exchange saturation transfer effect (GluCEST) between its amine group and bulk …

Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments

M Kim, J Gillen, BA Landman, J Zhou… - … in Medicine: An …, 2009‏ - Wiley Online Library
Chemical exchange saturation transfer (CEST) is a contrast mechanism that exploits
exchange‐based magnetization transfer (MT) between solute and water protons. CEST …

Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7 T

CK Jones, A Huang, J Xu, RAE Edden, M Schär, J Hua… - Neuroimage, 2013‏ - Elsevier
Chemical exchange saturation transfer (CEST) is a magnetization transfer (MT) technique to
indirectly detect pools of exchangeable protons through the water signal. CEST MRI has …

Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods

M Zaiss, P Bachert - Physics in Medicine & Biology, 2013‏ - iopscience.iop.org
Chemical exchange saturation transfer (CEST) of metabolite protons that undergo exchange
processes with the abundant water pool enables a specific contrast for magnetic resonance …

CEST: from basic principles to applications, challenges and opportunities

E Vinogradov, AD Sherry, RE Lenkinski - Journal of magnetic resonance, 2013‏ - Elsevier
Chemical Exchange Saturation Transfer (CEST) offers a new type of contrast for MRI that is
molecule specific. In this approach, a slowly exchanging NMR active nucleus, typically a …

Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors

J Zhou, M Zaiss, L Knutsson, PZ Sun… - Magnetic resonance …, 2022‏ - Wiley Online Library
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain
tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially …