[HTML][HTML] Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

M Liao, D Yao, L Wu, C Luo, Z Wang, J Zhang… - … Pharmaceutica Sinica B, 2024 - Elsevier
Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

Advancing cell surface modification in mammalian cells with synthetic molecules

H Yang, L Yao, Y Wang, G Chen, H Chen - Chemical Science, 2023 - pubs.rsc.org
Biological cells, being the fundamental entities of life, are widely acknowledged as intricate
living machines. The manipulation of cell surfaces has emerged as a progressively …

Site-selected in situ polymerization for living cell surface engineering

Y Zhong, L Xu, C Yang, L Xu, G Wang, Y Guo… - Nature …, 2023 - nature.com
The construction of polymer-based mimicry on cell surface to manipulate cell behaviors and
functions offers promising prospects in the field of biotechnology and cell therapy. However …

Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis

X Guo, J Bai, G Ge, Z Wang, Q Wang, K Zheng… - Journal of Colloid and …, 2022 - Elsevier
In the inflammatory peri-implant microenvironment, excessive polarization of macrophages
to the proinflammatory M1 phenotype can trigger the secretion of inflammatory cytokines …

Specific recognition to create nanofunctionalized cells for precise functions

TK Zhang, W Geng, YQ Huang, FZ Wang, G Tian… - Coordination Chemistry …, 2024 - Elsevier
Specific recognition sites exist in cells to bring about encapsulation and consequent
enhancements in stability and selectivity. Methods to create nanofunctionalized cells have …

Local detection of pH-induced disaggregation of biocompatible micelles by fluorescence switch ON

G Battistelli, M Proetto, A Mavridi-Printezi… - Chemical …, 2022 - pubs.rsc.org
Fluorogenic nanoparticles (NPs) able to sense different physiological environments and
respond with disaggregation and fluorescence switching OFF/ON are powerful tools in …

Integrating Metabolic Oligosaccharide Engineering and SPAAC Click Chemistry for Constructing Fibrinolytic Cell Surfaces

S Liu, H Yang, X Heng, L Yao, W Sun… - … Applied Materials & …, 2024 - ACS Publications
To effectively solve the problem of significant loss of transplanted cells caused by
thrombosis during cell transplantation, this study simulates the human fibrinolytic system and …

Covalent recruitment of polymers and nanoparticles onto glycan-engineered cells enhances gene delivery during short exposure

Q Tang, RMF Tomás, MI Gibson - Chemical Science, 2024 - pubs.rsc.org
Non-viral gene delivery with cationic polymers/nanoparticles relies on iterative optimization
of the carrier to achieve delivery. Here we demonstrate, instead, that precision engineering …

生体直交型反応による細胞とハイドロゲルの融合, 医療応用を目指して

長濱宏治 - ファルマシア, 2021 - jstage.jst.go.jp
抄録 細胞が本来もたない反応性官能基を細胞に導入することは, 生体直交型反応を介した機能性
分子による細胞エンジニアリングを可能とし, 細胞の機能制御や新規機能を付与した細胞の創出に …