Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …

Intestinal mucus forms the first line of defense against bacterial invasion while providing
nutrition to support microbial symbiosis. How the host controls mucus barrier integrity and …

The molecular basis for breast cancer metastasis to the brain is largely unknown,. Brain
relapse typically occurs years after the removal of a breast tumour,,, suggesting that …

Siglecs are a family of sialic acid–binding receptors expressed by cells of the immune
system and a few other cell types capable of modulating immune cell functions upon …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids.
Natural existing sialic acid-containing structures are presented in different sialic acid forms …

Glycans linked to proteins and lipids play key roles in biology; thus, accurate replication of
cellular glycans is crucial for maintaining function following cell division. The fact that …

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

The Siglecs (sialic acid-binding immunoglobulin-like lectins) are glycoimmune checkpoint
receptors that suppress immune cell activation upon engagement of cognate sialoglycan …