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Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …
participate broadly in human health, physiology and disease. Cilia generate a unique …
Structural biology of cilia and intraflagellar transport
Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …
Motile ciliopathies
Motile cilia are highly complex hair-like organelles of epithelial cells lining the surface of
various organ systems. Genetic mutations (usually with autosomal recessive inheritance) …
various organ systems. Genetic mutations (usually with autosomal recessive inheritance) …
Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry
The breaking of bilateral symmetry in most vertebrates is critically dependent upon the
motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid …
motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid …
[HTML][HTML] Brain lateralization: a comparative perspective
O Güntürkün, F Ströckens… - Physiological …, 2020 - journals.physiology.org
Comparative studies on brain asymmetry date back to the 19th century but then largely
disappeared due to the assumption that lateralization is uniquely human. Since the …
disappeared due to the assumption that lateralization is uniquely human. Since the …
Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association
This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
Genetics and genomics of congenital heart disease
Congenital heart disease is the most common birth defect, and because of major advances
in medical and surgical management, there are now more adults living with congenital heart …
in medical and surgical management, there are now more adults living with congenital heart …
Hydrodynamic theory of active matter
We review the general hydrodynamic theory of active soft materials that is motivated in
particular by biological matter. We present basic concepts of irreversible thermodynamics of …
particular by biological matter. We present basic concepts of irreversible thermodynamics of …
The intraflagellar transport machinery
M Taschner, E Lorentzen - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the
cell surface. The unique location and properties of cilia allow them to function in vital …
cell surface. The unique location and properties of cilia allow them to function in vital …
Primary cilia are not calcium-responsive mechanosensors
M Delling, AA Indzhykulian, X Liu, Y Li, T **e, DP Corey… - Nature, 2016 - nature.com
Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the
surface of cells between cell divisions. Their antenna-like structure leads naturally to the …
surface of cells between cell divisions. Their antenna-like structure leads naturally to the …