Emerging mechanistic understanding of cilia function in cellular signalling

KI Hilgendorf, BR Myers, JF Reiter - Nature Reviews Molecular Cell …, 2024 - nature.com
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Structural biology of cilia and intraflagellar transport

N Klena, G Pigino - Annual Review of Cell and Developmental …, 2022 - annualreviews.org
Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …

Motile ciliopathies

J Wallmeier, KG Nielsen, CE Kuehni… - Nature reviews Disease …, 2020 - nature.com
Motile cilia are highly complex hair-like organelles of epithelial cells lining the surface of
various organ systems. Genetic mutations (usually with autosomal recessive inheritance) …

Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry

L Djenoune, M Mahamdeh, TV Truong, CT Nguyen… - Science, 2023 - science.org
The breaking of bilateral symmetry in most vertebrates is critically dependent upon the
motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid …

[HTML][HTML] Brain lateralization: a comparative perspective

O Güntürkün, F Ströckens… - Physiological …, 2020 - journals.physiology.org
Comparative studies on brain asymmetry date back to the 19th century but then largely
disappeared due to the assumption that lateralization is uniquely human. Since the …

Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association

ME Pierpont, M Brueckner, WK Chung, V Garg… - Circulation, 2018 - ahajournals.org
This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Genetics and genomics of congenital heart disease

S Zaidi, M Brueckner - Circulation research, 2017 - ahajournals.org
Congenital heart disease is the most common birth defect, and because of major advances
in medical and surgical management, there are now more adults living with congenital heart …

Hydrodynamic theory of active matter

F Jülicher, SW Grill, G Salbreux - Reports on Progress in Physics, 2018 - iopscience.iop.org
We review the general hydrodynamic theory of active soft materials that is motivated in
particular by biological matter. We present basic concepts of irreversible thermodynamics of …

The intraflagellar transport machinery

M Taschner, E Lorentzen - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the
cell surface. The unique location and properties of cilia allow them to function in vital …

Primary cilia are not calcium-responsive mechanosensors

M Delling, AA Indzhykulian, X Liu, Y Li, T **e, DP Corey… - Nature, 2016 - nature.com
Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the
surface of cells between cell divisions. Their antenna-like structure leads naturally to the …