Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

Epithelial and endothelial monolayers are multicellular sheets that form barriers between the
'outside'and 'inside'of tissues. Cell-cell junctions, made by adherens junctions, tight junctions …

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How
talin and vinculin respond to forces and regulate one another remains unclear. By …

Epithelia act as barriers against environmental stresses. They are continuously exposed to
various mechanical stress and abrasion, which impact epithelial integrity. The impact of the …

Communities of epithelial cells communicate through intercellular interactions, allowing
them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and …

To enter mitosis, most adherent animal cells reduce adhesion, which is followed by cell
rounding. How mitotic cells regulate adhesion to neighboring cells and extracellular matrix …

Live tissues can self‐organize and be described as active materials composed of cells that
generate active stresses through continuous injection of energy. In vitro reconstituted …

Studying how epithelia respond to mechanical stresses is key to understanding tissue shape
changes during morphogenesis. Here, we study the viscoelastic properties of the Drosophila …

Since material stiffness controls many cell functions, we reviewed the currently available
knowledge on stiffness sensing and elucidated what is known in the context of clinical and …