Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Resveratrol is a polyphenol that has been shown to possess many applications in different
fields of medicine. This systematic review has drawn attention to the axis between …

Despite tremendous medical treatment successes, colorectal cancer (CRC) remains a
leading cause of cancer deaths worldwide. Chemotherapy as monotherapy can lead to …

Background The gut microbiota (GM)–bone axis has emerged as a crucial mediator of bone
homeostasis. Estrogen deficiency–induced bone loss is closely associated with an altered …

The imbalance between osteogenesis and osteoclastogenesis is a feature of bone
metabolic disease. Cadmium (Cd) exposure causes human bone loss and osteoporosis …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Abstract Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase,
epigenetically regulates various cell metabolisms, including inflammation, tumorigenesis …

Rational: Senescence of mesenchymal stem cells (MSCs) and the related functional decline
of osteogenesis have emerged as the critical pathogenesis of osteoporosis in aging …

Osteoporosis (OP) is a systemic skeletal disorder characterized by reduced bone mass and
structural deterioration of bone tissue, resulting in heightened vulnerability to fractures due …

Osteoporosis is a complex multifactorial disorder of the skeleton. Genetic factors are
important in determining peak bone mass and structure, as well as the predisposition to …